Positive regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Positive regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are L3HYPDH, NRP1, and PPM1F, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of substrate adhesion-dependent cell spreading activity versus L3HYPDH in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	L3HYPDH →	+0.355	+0.037	<.001	.001	3	8
GBM	NRP1 →	+0.525	+0.049	.004	.001	3	8
BRCA	PPM1F →	+0.251	+0.041	<.001	<.001	2	9
LSCC	LGALS1 →	+0.572	+0.059	<.001	<.001	3	8
OV	C1QB →	+0.670	+0.059	<.001	<.001	3	7
BRCA	C6 →	+0.555	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900026 vs L3HYPDH — BRCA

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