Positive regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Positive regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, TAGLN, and IGFBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of substrate adhesion-dependent cell spreading activity versus ITGB1 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGB1 →	+0.657	+0.157	<.001	.005	3	8
COAD	TAGLN →	+1.558	+0.574	<.001	.004	2	8
OV	IGFBP7 →	+1.112	+0.119	<.001	<.001	3	7
OV	ACTA2 →	+1.513	+0.121	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.833	+0.251	<.001	<.001	3	7
LSCC	MMP19 →	+1.057	+0.606	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900026 vs ITGB1 — BRCA

Explore this scatter interactively →