Positive regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Positive regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8A, C2, and C8B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of substrate adhesion-dependent cell spreading activity versus C8A in COAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C8A →	+0.657	+0.658	<.001	.003	3	8
PDAC	C2 →	+0.580	+0.125	<.001	<.001	2	8
CCRCC	C8B →	+0.723	+0.209	<.001	.005	2	8
CCRCC	CFH →	+0.659	+0.136	<.001	.007	2	8
PDAC	HPX →	+0.575	+0.123	<.001	<.001	3	7
OV	KLKB1 →	+0.625	+0.118	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900026 vs C8A — COAD

Explore this scatter interactively →