Positive regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Positive regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN4, RNF122, and TIMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN4 grouped by Positive regulation of substrate adhesion-dependent cell spreading-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TSPAN4 →	+2.819	+0.396	<.001	<.001	3	5
LARGE_INTESTINE	RNF122 →	+0.764	+0.319	<.001	<.001	3	4
LARGE_INTESTINE	TIMP2 →	+2.619	+0.327	.008	.007	3	4
CNS	TMEM14C →	+0.580	+0.284	.008	.007	3	4
PANCREAS	PMPCA →	-0.861	-0.362	.002	.002	3	4
STOMACH	GPRASP2 →	+1.017	+0.261	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN4 by Positive regulation of substrate adhesion-dependent cell spreading activity — STOMACH

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