Positive regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Positive regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A10, RPL3, and RTKN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of substrate adhesion-dependent cell spreading activity versus S100A10 in OVARY (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	S100A10 →	+2.471	+0.233	.002	.001	3	7
OVARY	RPL3 →	-0.685	-0.196	.008	.004	3	5
BREAST	RTKN →	-1.220	-0.188	.001	<.001	3	5
BREAST	RNF217 →	+1.077	+0.181	.009	.005	3	5
LARGE_INTESTINE	CAV2 →	+2.159	+0.150	<.001	.001	3	5
LARGE_INTESTINE	FLNB →	+1.037	+0.186	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900026 vs S100A10 — OVARY

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