Negative regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Negative regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WWC3_S957, EFEMP2, and EFEMP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of substrate adhesion-dependent cell spreading activity versus WWC3_S957 in OV (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WWC3_S957 →	+0.438	+0.038	.003	.005	3	6
OV	EFEMP2 →	+0.591	+0.055	<.001	<.001	3	6
OV	EFEMP1 →	+0.779	+0.056	<.001	<.001	3	5
BRCA	MELTF →	+0.810	+0.056	<.001	<.001	3	5
CCRCC	IGFBP7 →	+0.701	+0.059	.003	.002	3	5
HNSC	NECAP1 →	-0.167	-0.069	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900025 vs WWC3_S957 — OV

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