Negative regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Negative regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALAS2, TAL1, and HBA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of substrate adhesion-dependent cell spreading activity versus ALAS2 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALAS2 →	+0.877	+0.257	.003	<.001	3	3
GBM	TAL1 →	+0.637	+0.203	.002	.001	3	3
GBM	HBA2 →	+1.405	+0.185	<.001	.005	3	3
GBM	DMD →	+0.685	+0.173	.008	.002	3	3
GBM	MIR23B →	+0.350	+0.168	.005	.001	3	3
HNSC	LDB3 →	-0.749	-0.089	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900025 vs ALAS2 — GBM

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