Negative regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Negative regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTN4, GBP1, and NR1I2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTN4 grouped by Negative regulation of substrate adhesion-dependent cell spreading-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACTN4 →	-0.183	-1.088	.002	<.001	3	7
LARGE_INTESTINE	GBP1 →	-0.229	-1.051	.001	.001	3	6
LIVER	NR1I2 →	-0.163	-1.193	.006	.003	3	5
LIVER	ACO2 →	-0.497	-1.776	.006	<.001	3	4
LUNG_NSCLC_LUSC	RRAS →	-0.130	-1.378	.008	.009	3	4
SOFT_TISSUE	CRK →	+0.281	+1.618	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTN4 by Negative regulation of substrate adhesion-dependent cell spreading activity — OVARY

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