Negative regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Negative regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPRV1, MGST2, and PPP1R8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASPRV1 grouped by Negative regulation of substrate adhesion-dependent cell spreading-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASPRV1 →	+0.753	+1.140	.001	.008	3	4
PANCREAS	MGST2 →	+1.253	+1.204	<.001	.001	3	4
BLOOD_Leukemia	PPP1R8 →	+0.560	+1.551	.004	<.001	3	3
BLOOD_Leukemia	RNF2 →	+1.027	+1.168	.007	.005	3	3
BLOOD_Leukemia	HP1BP3 →	+0.793	+1.024	.001	.001	3	3
BLOOD_Leukemia	MAP3K12 →	+0.894	+1.059	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASPRV1 by Negative regulation of substrate adhesion-dependent cell spreading activity — BLOOD_Leukemia

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