Negative regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Negative regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSIP1, SNX33, and CEP70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of substrate adhesion-dependent cell spreading activity versus PSIP1 in BONE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PSIP1 →	+1.027	+0.440	.005	.002	3	5
LUNG_SCLC	SNX33 →	-1.898	-0.299	<.001	.001	3	5
BREAST	CEP70 →	+1.010	+0.242	.001	.002	3	5
URINARY_TRACT	SAMD15 →	+1.228	+0.310	.001	<.001	3	4
CNS	APMAP →	-0.983	-0.245	<.001	.001	3	4
LUNG_SCLC	SECISBP2L →	-0.577	-0.221	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900025 vs PSIP1 — BONE

Explore this scatter interactively →