Regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1QC, P4HA2, and VIM_S72, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of substrate adhesion-dependent cell spreading activity versus C1QC in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1QC →	+0.916	+0.064	<.001	<.001	3	7
LSCC	P4HA2 →	+0.601	+0.050	<.001	<.001	3	7
BRCA	VIM_S72 →	+0.680	+0.030	<.001	<.001	3	7
OV	CCN1 →	+0.844	+0.068	<.001	<.001	3	7
OV	LUM →	+0.915	+0.050	<.001	.003	3	7
UCEC	NES →	+0.421	+0.058	.007	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900024 vs C1QC — OV

Explore this scatter interactively →