Regulation of substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALD1, MIR4435-2HG, and TCF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of substrate adhesion-dependent cell spreading activity versus CALD1 in UCEC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CALD1 →	+1.032	+0.249	.006	.006	3	7
LUAD	MIR4435-2HG →	+0.524	+0.126	.007	<.001	3	6
CCRCC	TCF4 →	+0.674	+0.146	<.001	<.001	3	6
BRCA	CHSY3 →	+0.471	+0.140	<.001	<.001	3	6
UCEC	FERMT2 →	+0.882	+0.269	.005	.004	2	7
BRCA	ZEB1 →	+0.746	+0.144	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900024 vs CALD1 — UCEC

Explore this scatter interactively →