Regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMACHC, CLUH, and STIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMACHC grouped by Regulation of substrate adhesion-dependent cell spreading-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MMACHC →	-0.990	-0.942	<.001	.006	3	4
LIVER	CLUH →	-0.979	-0.901	<.001	.009	3	3
LIVER	STIM1 →	+1.338	+1.224	.002	.009	3	3
CNS	C11orf52 →	+0.477	+0.406	.002	.007	3	3
OESOPHAGUS	CYP51A1 →	-1.438	-0.176	.004	.006	3	3
LARGE_INTESTINE	SGK1 →	+1.644	+0.375	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMACHC by Regulation of substrate adhesion-dependent cell spreading activity — LIVER

Explore this box plot interactively →