Regulation of protein kinase C activity

Across TCGA patient cohorts, RNA activity of the Regulation of protein kinase C activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBE1, DIPK2A, and RSF1_S604, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein kinase C activity activity versus GBE1 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBE1 →	+0.393	+0.062	.001	.008	3	6
HNSC	DIPK2A →	+0.442	+0.073	<.001	<.001	3	6
GBM	RSF1_S604 →	-0.256	-0.082	.006	.002	3	5
BRCA	TGFB1I1 →	+0.703	+0.106	<.001	<.001	3	5
BRCA	ACTN1 →	+0.496	+0.100	<.001	<.001	3	5
UCEC	TSHZ2_S332 →	+0.604	+0.101	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900019 vs GBE1 — BRCA

Explore this scatter interactively →