Regulation of protein kinase C activity

Across TCGA cell cohorts, RNA activity of the Regulation of protein kinase C activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3D21, ABCA2, and PRX, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3D21 grouped by Regulation of protein kinase C activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SH3D21 →	+2.220	+1.262	.004	.003	3	3
OESOPHAGUS	ABCA2 →	+1.532	+0.276	<.001	.005	3	3
SKIN	PRX →	+0.365	+0.892	.007	.005	3	3
BONE	TMEM240 →	-2.660	-1.913	.002	.002	3	3
SOFT_TISSUE	DBP →	+1.684	+1.658	.004	.002	3	2
KIDNEY	PHEX →	+1.367	+1.633	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3D21 by Regulation of protein kinase C activity activity — KIDNEY

Explore this box plot interactively →