Positive regulation of cytokine production involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytokine production involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCB2, GNGT2, and KIAA1549, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytokine production involved in inflammatory response activity versus PLCB2 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLCB2 →	+0.711	+0.242	<.001	<.001	3	6
LSCC	GNGT2 →	+0.655	+0.255	<.001	<.001	3	6
LSCC	KIAA1549 →	-0.661	-0.128	.001	.006	3	6
LSCC	NCF4 →	+0.666	+0.198	<.001	<.001	3	5
LSCC	TNFSF13B →	+0.836	+0.258	<.001	<.001	3	5
HNSC	BTK →	+0.699	+0.300	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900017 vs PLCB2 — LSCC

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