Positive regulation of cytokine production involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytokine production involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA13, YME1L1, and SLC9A3R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA13 grouped by Positive regulation of cytokine production involved in inflammatory response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPATA13 →	-1.014	-0.687	.002	.001	3	4
BLOOD_Leukemia	YME1L1 →	+0.572	+0.750	.005	.007	3	4
BREAST	SLC9A3R1 →	-2.435	-0.820	<.001	.008	2	4
BREAST	DEPDC7 →	+1.334	+0.941	<.001	.002	3	3
BREAST	GDPD1 →	-0.872	-0.773	.003	.006	2	4
BREAST	MAML3 →	-0.957	-0.975	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA13 by Positive regulation of cytokine production involved in inflammatory response activity — CNS

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