Positive regulation of cytokine production involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytokine production involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN11, SNRNP40, and DDB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytokine production involved in inflammatory response activity versus PTPN11 in BLOOD_Myeloma (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PTPN11 →	+0.705	+1.348	<.001	.001	3	4
LIVER	SNRNP40 →	+0.704	+0.346	.002	.004	3	4
PANCREAS	DDB1 →	+0.718	+1.320	<.001	.006	3	4
CNS	SSRP1 →	+0.610	+0.705	<.001	.002	3	4
CNS	EIF3I →	+0.455	+0.645	.002	.005	3	4
BLOOD_Leukemia	GATAD2A →	+0.575	+0.993	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900017 vs PTPN11 — BLOOD_Myeloma

Explore this scatter interactively →