Negative regulation of cytokine production involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytokine production involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, NCAPG, and MAD2L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytokine production involved in inflammatory response activity versus CDKN3 in CCRCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDKN3 →	-0.402	-0.096	<.001	<.001	3	4
CCRCC	NCAPG →	-0.710	-0.105	.001	.006	3	4
CCRCC	MAD2L1 →	-0.653	-0.148	<.001	<.001	3	4
GBM	PLAUR →	-0.887	-0.285	<.001	<.001	3	4
GBM	APLN →	-0.709	-0.232	<.001	<.001	3	4
OV	CCT3 →	-0.453	-0.138	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900016 vs CDKN3 — CCRCC

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