Negative regulation of cytokine production involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytokine production involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H12A, MVP, and SEMA4B, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytokine production involved in inflammatory response activity versus ZC3H12A in SOFT_TISSUE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZC3H12A →	+1.773	+0.118	<.001	<.001	3	14
LUNG_NSCLC_LUSC	MVP →	+2.503	+0.102	<.001	.004	3	13
OVARY	SEMA4B →	+1.319	+0.089	<.001	.001	3	13
OVARY	IL15RA →	+1.716	+0.098	<.001	<.001	3	12
BLOOD_Lymphoma	MOB3C →	+1.062	+0.068	.001	<.001	3	12
BONE	SPSB1 →	+1.465	+0.124	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900016 vs ZC3H12A — SOFT_TISSUE

Explore this scatter interactively →