Positive regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendrite development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, FCER1G, and HCK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendrite development activity versus AIF1 in HNSC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AIF1 →	-0.517	-0.089	<.001	.001	3	7
UCEC	FCER1G →	-0.671	-0.056	.003	.006	3	6
LSCC	HCK →	-0.453	-0.088	<.001	.001	3	6
UCEC	PKP4 →	+0.452	+0.100	<.001	<.001	3	6
HNSC	PTPRC →	-0.586	-0.095	<.001	<.001	3	6
GBM	RGS10 →	-0.401	-0.051	.003	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900006 vs AIF1 — HNSC

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