Positive regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COBL, DDAH1, and DOLPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendrite development activity versus COBL in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COBL →	+0.694	+0.683	<.001	<.001	3	6
CCRCC	DDAH1 →	+0.579	+0.217	.001	.002	3	6
LSCC	DOLPP1 →	+0.449	+0.181	<.001	<.001	2	6
UCEC	ADGRV1 →	+1.644	+1.245	<.001	<.001	3	5
UCEC	FAM118B →	+0.530	+0.857	.003	.006	3	5
CCRCC	DAB2IP →	+0.660	+0.270	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900006 vs COBL — BRCA

Explore this scatter interactively →