Positive regulation of dendrite development

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGMS2, TET3, and SERPINE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGMS2 grouped by Positive regulation of dendrite development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SGMS2 →	-1.823	-1.221	<.001	.001	3	5
LUNG_SCLC	TET3 →	+0.873	+0.656	<.001	.003	3	4
CNS	SERPINE1 →	-2.396	-1.040	.006	<.001	3	4
CNS	OPTN →	-1.222	-0.978	.001	.002	3	4
CNS	APEX2 →	-0.647	-1.241	.007	<.001	3	4
CNS	CCDC183 →	+0.480	+0.935	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGMS2 by Positive regulation of dendrite development activity — LIVER

Explore this box plot interactively →