"Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway"

Across TCGA patient cohorts, RNA activity of the "Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POGZ, TRIM33, and IPO9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway" activity versus POGZ in HNSC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POGZ →	+0.354	+0.106	<.001	<.001	3	7
GBM	TRIM33 →	+0.262	+0.054	<.001	.004	3	6
LSCC	IPO9 →	+0.368	+0.065	<.001	<.001	3	6
HNSC	RPRD2 →	+0.261	+0.077	<.001	<.001	3	6
HNSC	ZNF638 →	+0.352	+0.090	<.001	<.001	3	6
HNSC	CDC73 →	+0.306	+0.108	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0180012 vs POGZ — HNSC

Explore this scatter interactively →