"Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway"

Across TCGA cell cohorts, RNA activity of the "Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, TP53INP2, and CMBL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway" activity versus TMED3 in LUNG_NSCLC_LUAD (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMED3 →	-0.985	-0.270	<.001	<.001	3	5
LIVER	TP53INP2 →	-1.092	-0.230	<.001	.001	3	5
BLOOD_Lymphoma	CMBL →	-2.106	-0.173	.003	.002	2	5
BLOOD_Lymphoma	TARS3 →	-1.083	-0.113	.002	.008	3	4
BREAST	SAR1B →	-0.904	-0.226	<.001	.004	3	4
BONE	STX10 →	-1.228	-0.301	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0180012 vs TMED3 — LUNG_NSCLC_LUAD

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