"Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"

Across TCGA patient cohorts, RNA activity of the "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, CDC73, and GATAD2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" activity versus RPRD2 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPRD2 →	+0.210	+0.073	<.001	<.001	3	7
LSCC	CDC73 →	+0.209	+0.042	<.001	<.001	3	6
HNSC	GATAD2B →	+0.271	+0.083	.001	<.001	2	7
LSCC	IPO9 →	+0.417	+0.073	<.001	<.001	3	6
HNSC	IWS1 →	+0.240	+0.077	<.001	<.001	3	6
HNSC	POGZ →	+0.334	+0.104	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0180010 vs RPRD2 — HNSC

Explore this scatter interactively →