"Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"

Across TCGA patient cohorts, RNA activity of the "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AEBP1, GLT8D2, and TMEM45A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" activity versus AEBP1 in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AEBP1 →	-0.858	-0.198	.001	.001	3	5
LSCC	GLT8D2 →	-0.654	-0.256	.007	<.001	3	5
HNSC	TMEM45A →	-0.859	-0.112	<.001	.001	3	5
GBM	ANGPTL4 →	-0.977	-0.132	.005	.001	3	5
GBM	MMP19 →	-1.179	-0.155	.001	.003	3	5
GBM	PLPP4 →	-1.082	-0.156	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0180010 vs AEBP1 — LSCC

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