"Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"

Across TCGA cell cohorts, RNA activity of the "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIX1L, RNF103, and MBD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway" activity versus LIX1L in LUNG_NSCLC_LUSC (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LIX1L →	-2.560	-0.358	.009	<.001	3	5
BREAST	RNF103 →	-0.774	-0.157	.003	.008	3	5
LUNG_NSCLC_LUSC	MBD1 →	-1.337	-0.403	<.001	.001	3	4
LUNG_NSCLC_LUSC	ATG12 →	-0.971	-0.275	.002	.008	3	4
OESOPHAGUS	CRAT →	-3.153	-0.209	<.001	<.001	3	4
BLOOD_Myeloma	DBN1 →	+2.030	+0.210	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0180010 vs LIX1L — LUNG_NSCLC_LUSC

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