Multi-pass transmembrane protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Multi-pass transmembrane protein insertion into ER membrane pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMCO1, APPL1, and CALR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-pass transmembrane protein insertion into ER membrane activity versus TMCO1 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMCO1 →	+0.867	+0.069	<.001	<.001	3	7
BRCA	APPL1 →	-0.228	-0.075	<.001	<.001	3	5
BRCA	CALR →	+0.309	+0.065	<.001	<.001	3	5
LUAD	RBSN →	-0.226	-0.085	.001	<.001	3	5
LUAD	STT3B_S29 →	+0.442	+0.056	<.001	<.001	3	5
CCRCC	ZNF622_S143 →	+0.557	+0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0160063 vs TMCO1 — UCEC

Explore this scatter interactively →