Multi-pass transmembrane protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Multi-pass transmembrane protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS23, LCA5, and SHPRH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-pass transmembrane protein insertion into ER membrane activity versus RPS23 in COAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS23 →	-0.291	-0.115	.007	.005	3	4
CCRCC	LCA5 →	-0.430	-0.187	.004	.007	3	4
PDAC	SHPRH →	-0.162	-0.148	.005	.009	3	4
PDAC	CFAP44 →	-0.317	-0.160	<.001	.004	3	4
LSCC	GPRASP2 →	-0.486	-0.111	<.001	.009	3	4
UCEC	PDIA2 →	-1.153	-0.211	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0160063 vs RPS23 — COAD

Explore this scatter interactively →