Multi-pass transmembrane protein insertion into ER membrane

Across TCGA cell cohorts, RNA activity of the Multi-pass transmembrane protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC38A10, METTL9, and DNAJC30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC38A10 grouped by Multi-pass transmembrane protein insertion into ER membrane-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC38A10 →	+1.870	+1.778	.003	.003	3	4
SKIN	METTL9 →	+0.669	+1.065	.007	.009	3	4
BLOOD_Lymphoma	DNAJC30 →	+1.850	+1.861	.007	.002	3	4
LUNG_SCLC	FXR2 →	+0.789	+1.035	<.001	.001	3	4
LUNG_SCLC	RNASEK →	+1.350	+1.623	.001	<.001	3	4
LARGE_INTESTINE	SPAG7 →	+0.911	+1.362	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC38A10 by Multi-pass transmembrane protein insertion into ER membrane activity — BLOOD_Lymphoma

Explore this box plot interactively →