Multi-pass transmembrane protein insertion into ER membrane

Across TCGA cell cohorts, RNA activity of the Multi-pass transmembrane protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, PDLIM1, and CRACD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-pass transmembrane protein insertion into ER membrane activity versus SDC4 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SDC4 →	+2.715	+0.369	.007	<.001	3	9
LUNG_NSCLC_LUSC	PDLIM1 →	+2.905	+0.252	.003	.002	3	7
STOMACH	CRACD →	-1.953	-0.264	<.001	.003	3	7
STOMACH	RAB5IF →	+1.365	+0.323	<.001	.002	3	6
OESOPHAGUS	WNT10A →	+2.485	+0.260	<.001	<.001	3	6
LUNG_NSCLC_LUAD	C3 →	+3.300	+0.209	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0160063 vs SDC4 — STOMACH

Explore this scatter interactively →