Cell junction disassembly

Across TCGA patient cohorts, RNA activity of the Cell junction disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE2, RGS19, and SEC23A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction disassembly activity versus MAPRE2 in OV (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAPRE2 →	+0.397	+0.132	<.001	<.001	3	4
OV	RGS19 →	+0.646	+0.199	<.001	<.001	3	3
OV	SEC23A →	+0.264	+0.114	<.001	<.001	3	3
UCEC	STK10_S417 →	+0.927	+0.772	<.001	<.001	3	3
GBM	STXBP1_S516 →	+1.285	+0.170	<.001	<.001	3	3
OV	SYNE3 →	+0.347	+0.138	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150146 vs MAPRE2 — OV

Explore this scatter interactively →