Cell junction disassembly

Across TCGA cell cohorts, RNA activity of the Cell junction disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKK1, C3, and NKX3-1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction disassembly activity versus DKK1 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DKK1 →	+4.925	+0.162	.001	.001	3	12
SOFT_TISSUE	C3 →	+3.665	+0.163	<.001	.003	3	12
BONE	NKX3-1 →	+1.293	+0.105	.004	.001	3	8
BREAST	KCNJ11 →	-1.350	-0.124	<.001	<.001	3	8
BONE	MEX3A →	-2.440	-0.124	<.001	.002	3	8
BLOOD_Lymphoma	PFAS →	-0.781	-0.079	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150146 vs DKK1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →