Cell junction disassembly

Across TCGA cell cohorts, RNA activity of the Cell junction disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPRG1, ZSCAN5A, and ZNF133, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction disassembly activity versus TPRG1 in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TPRG1 →	-1.044	-0.842	.002	.002	3	4
CNS	ZSCAN5A →	-0.811	-0.294	.001	<.001	3	4
STOMACH	ZNF133 →	-0.951	-1.213	<.001	.001	3	3
LUNG_NSCLC_LUAD	ACTL10 →	+0.870	+0.941	.001	.008	3	3
LUNG_NSCLC_LUAD	CSNK1E →	+0.764	+0.752	.003	.004	3	3
BREAST	CYP2D7 →	+0.713	+1.110	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150146 vs TPRG1 — BREAST

Explore this scatter interactively →