Negative regulation of cell-substrate junction organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1A1P9, RN7SKP80, and EEF1A1P8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-substrate junction organization activity versus EEF1A1P9 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EEF1A1P9 →	+1.584	+0.578	.001	.005	3	5
UCEC	RN7SKP80 →	+1.455	+0.695	.003	.009	3	4
COAD	EEF1A1P8 →	+0.552	+0.428	<.001	.007	3	4
UCEC	MTND6P3 →	+1.716	+0.600	.001	.004	3	4
UCEC	EIF4G1 →	-0.700	-0.662	<.001	.003	3	4
UCEC	DDX11 →	-0.666	-0.598	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150118 vs EEF1A1P9 — UCEC

Explore this scatter interactively →