Negative regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXRA7, TIAM2, and GNB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MXRA7 grouped by Negative regulation of cell-substrate junction organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MXRA7 →	-3.685	-1.449	.001	.001	3	5
SOFT_TISSUE	TIAM2 →	-1.572	-1.202	.007	.004	3	4
BLOOD_Myeloma	GNB5 →	+0.871	+1.129	.004	.001	3	4
BLOOD_Lymphoma	GAR1 →	+0.963	+1.631	<.001	.001	3	4
BLOOD_Lymphoma	SMARCA5 →	+1.162	+1.694	.007	<.001	3	4
LARGE_INTESTINE	AIF1L →	+2.142	+0.956	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MXRA7 by Negative regulation of cell-substrate junction organization activity — STOMACH

Explore this box plot interactively →