Cell-substrate junction organization

Across TCGA patient cohorts, RNA activity of the Cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1R1, CD40LG, and EFEMP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-substrate junction organization activity versus IL1R1 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL1R1 →	+1.951	+0.366	.007	.007	3	3
OV	CD40LG →	+1.146	+0.340	.002	.009	3	2
OV	EFEMP1 →	+4.123	+0.340	.002	.009	2	3
OV	ENOX1 →	+1.479	+0.340	.004	.009	3	2
OV	CD72 →	+1.756	+0.340	<.001	.009	3	2
OV	SDCBP →	+0.876	+0.340	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150115 vs IL1R1 — BRCA

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