Cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA7, UGDH, and ATF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDCA7 grouped by Cell-substrate junction organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CDCA7 →	+1.018	+0.941	.004	.006	3	5
BLOOD_Myeloma	UGDH →	+1.279	+1.853	.005	<.001	3	5
BLOOD_Myeloma	ATF4 →	+1.157	+1.564	.001	.001	3	4
KIDNEY	MAPRE1 →	+1.025	+1.654	.002	<.001	3	4
LIVER	SGK3 →	+1.055	+0.336	.007	.007	3	4
BLOOD_Leukemia	FAM186B →	+0.263	+0.856	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDCA7 by Cell-substrate junction organization activity — PANCREAS

Explore this box plot interactively →