Cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, ITPRID2, and IFI16, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-substrate junction organization activity versus FRAT2 in BREAST (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FRAT2 →	-1.136	-0.311	<.001	<.001	3	9
LUNG_NSCLC_LUSC	ITPRID2 →	+1.390	+0.333	<.001	.002	3	8
STOMACH	IFI16 →	+4.213	+0.336	.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	LRFN1 →	-0.964	-0.535	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	ANTXR2 →	+2.395	+0.334	.001	.002	3	7
BREAST	GKAP1 →	-0.956	-0.296	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150115 vs FRAT2 — BREAST

Explore this scatter interactively →