Protein localization to cell-cell junction

Across TCGA cell cohorts, RNA activity of the Protein localization to cell-cell junction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16A, NRIP2, and ATF7IP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R16A grouped by Protein localization to cell-cell junction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R16A →	-0.883	-0.223	.002	.002	3	4
OVARY	NRIP2 →	-0.415	-0.257	.004	<.001	3	3
LUNG_SCLC	ATF7IP2 →	-2.639	-0.347	.006	.004	3	3
LUNG_SCLC	CLPX →	-0.787	-0.382	.003	.003	3	3
LIVER	VRK3 →	-0.514	-0.276	.008	.004	3	3
LUNG_NSCLC_LUAD	CDKN1B →	-0.528	-0.527	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R16A by Protein localization to cell-cell junction activity — LARGE_INTESTINE

Explore this box plot interactively →