Protein localization to cell-cell junction

Across TCGA cell cohorts, RNA activity of the Protein localization to cell-cell junction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, CAPN1, and GJB3, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell-cell junction activity versus TJP2 in LUNG_SCLC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TJP2 →	+2.436	+0.169	.001	<.001	3	16
URINARY_TRACT	CAPN1 →	+1.719	+0.188	<.001	<.001	3	14
URINARY_TRACT	GJB3 →	+4.205	+0.201	<.001	<.001	3	13
URINARY_TRACT	SH2D3A →	+3.682	+0.197	<.001	<.001	3	13
OESOPHAGUS	MARK2 →	+0.859	+0.113	.005	.005	3	12
URINARY_TRACT	CDC42BPG →	+2.531	+0.151	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150105 vs TJP2 — LUNG_SCLC

Explore this scatter interactively →