Protein localization to cell-cell junction

Across TCGA cell cohorts, RNA activity of the Protein localization to cell-cell junction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, EXPH5, and SH2D3A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell-cell junction activity versus TJP2 in LUNG_SCLC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TJP2 →	+2.844	+0.350	.001	<.001	3	9
STOMACH	EXPH5 →	+2.070	+0.501	.003	.003	3	9
STOMACH	SH2D3A →	+3.740	+0.512	<.001	<.001	3	8
LIVER	CRB3 →	+3.751	+0.270	.001	<.001	2	9
LUNG_SCLC	F11R →	+2.997	+0.412	<.001	<.001	3	8
STOMACH	LAD1 →	+3.816	+0.429	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150105 vs TJP2 — LUNG_SCLC

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