Negative regulation of neuroinflammatory response

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, PIK3R5, and CYTH4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuroinflammatory response activity versus CSF2RB in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CSF2RB →	+1.151	+0.228	<.001	<.001	3	8
LSCC	PIK3R5 →	+0.650	+0.261	<.001	<.001	3	8
HNSC	CYTH4 →	+0.957	+0.180	<.001	.002	3	8
CCRCC	IL21R →	+1.039	+0.215	<.001	<.001	3	8
LSCC	ARHGAP9 →	+1.157	+0.417	<.001	.001	3	8
CCRCC	ITGAX →	+0.752	+0.151	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150079 vs CSF2RB — HNSC

Explore this scatter interactively →