Negative regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK1, NUP210L, and PHTF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuroinflammatory response activity versus NEK1 in LUNG_SCLC (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NEK1 →	+0.594	+1.376	<.001	<.001	3	4
BLOOD_Leukemia	NUP210L →	+0.028	+1.090	<.001	.002	3	4
BLOOD_Lymphoma	PHTF2 →	+0.777	+1.115	.002	<.001	3	4
OESOPHAGUS	MCCC2 →	-1.123	-2.035	.005	.003	3	3
LUNG_NSCLC_LUAD	FYTTD1 →	+0.610	+1.245	.006	<.001	3	3
STOMACH	PXYLP1 →	-1.165	-1.696	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150079 vs NEK1 — LUNG_SCLC

Explore this scatter interactively →