Positive regulation of neuroinflammatory response

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR223HG, PRAM1, and CEACAM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuroinflammatory response activity versus MIR223HG in LSCC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIR223HG →	+1.036	+0.669	<.001	<.001	3	7
LSCC	PRAM1 →	+0.479	+0.466	<.001	.001	3	6
LSCC	CEACAM3 →	+0.700	+0.522	<.001	<.001	3	6
LSCC	WASHC3 →	-0.347	-0.550	<.001	.001	3	5
BRCA	CLEC4E →	+1.240	+0.533	<.001	<.001	3	5
LSCC	CSF3R →	+1.254	+0.620	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150078 vs MIR223HG — LSCC

Explore this scatter interactively →