Positive regulation of neuroinflammatory response

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuroinflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACAP1_T739, LAT_S224, and RCSD1_S216, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuroinflammatory response activity versus ACAP1_T739 in LSCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACAP1_T739 →	+0.775	+0.533	<.001	<.001	3	6
LSCC	LAT_S224 →	+0.729	+0.503	<.001	<.001	3	5
OV	RCSD1_S216 →	+0.757	+0.491	<.001	.001	3	5
LSCC	RGS14_S288 →	+1.127	+0.780	<.001	<.001	3	5
HNSC	FMNL1 →	+0.629	+0.369	<.001	.001	3	5
BRCA	GIMAP8 →	+0.483	+0.379	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150078 vs ACAP1_T739 — LSCC

Explore this scatter interactively →