Positive regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUPR1, ZHX1, and MAPK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuroinflammatory response activity versus NUPR1 in SKIN (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NUPR1 →	+2.768	+0.207	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	ZHX1 →	+0.914	+0.175	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MAPK3 →	+1.195	+0.190	.001	<.001	3	5
LUNG_NSCLC_LUAD	BCL2L13 →	+0.706	+0.180	<.001	<.001	3	5
SOFT_TISSUE	NMB →	-0.887	-0.124	.001	.003	3	5
BLOOD_Leukemia	SNX29 →	+0.805	+0.109	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150078 vs NUPR1 — SKIN

Explore this scatter interactively →