Positive regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTD2, RAB11A, and R3HCC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuroinflammatory response activity versus DTD2 in PANCREAS (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DTD2 →	+0.902	+1.222	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	RAB11A →	+1.165	+1.922	<.001	<.001	3	5
LARGE_INTESTINE	R3HCC1 →	+0.822	+0.826	.006	.008	3	5
UPPER_AERODIGESTIVE_TRACT	UQCRC1 →	+0.860	+1.546	.001	.002	3	4
BLOOD_Leukemia	PPP2CB →	+0.783	+0.161	<.001	<.001	3	4
LARGE_INTESTINE	EXOSC9 →	+0.974	+1.186	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150078 vs DTD2 — PANCREAS

Explore this scatter interactively →