Regulation of neuroinflammatory response

Across TCGA patient cohorts, RNA activity of the Regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, CSF3R, and RIPOR2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuroinflammatory response activity versus MEFV in LSCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEFV →	+0.772	+0.318	<.001	<.001	3	8
LSCC	CSF3R →	+1.206	+0.405	<.001	<.001	3	7
LSCC	RIPOR2 →	+0.874	+0.369	<.001	<.001	3	7
LSCC	FPR2 →	+1.148	+0.330	<.001	<.001	3	7
HNSC	FCAR →	+0.666	+0.220	.001	<.001	3	7
COAD	LILRB3 →	+0.726	+0.227	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150077 vs MEFV — LSCC

Explore this scatter interactively →